Moléculas provenientes de alimentos con posibilidad de uso en el desarrollo de alimentos funcionales y nutracéuticos para el adulto mayor: una revisión narrativa
Resumen
En este texto se revisan diversas moléculas de origen natural, alimentos y probióticos con potencial uso en la prevención y el tratamiento de distintas enfermedades que afectan en mayor parte a los adultos mayores. Los adultos mayores son un grupo etario vulnerable que cada año representa un mayor porcentaje de la población mexicana y mundial, para el cual existen pocos alimentos funcionales y nutracéuticos. Se han investigado una gran cantidad de moléculas provenientes de alimentos con capacidad de uso en la formulación de alimentos y nutracéuticos, las cuales incluyen compuestos fenólicos, compuestos terpénicos, metabolitos primarios de plantas de naturaleza glucídica, lipídica, aminoacídica y purínica, prebióticos y probióticos, así como matrices alimentarias complejas. Patologías como las dislipidemias, la hipertensión arterial, la obesidad, la resistencia a la insulina, la diabetes mellitus tipo 2, el cáncer y las cardiopatías constituyen las mayores causas de muerte en el mundo, siendo en gran parte prevenibles a través de la alimentación, el ejercicio físico y un estilo de vida saludable. El objetivo de este trabajo fue concientizar al lector de la importancia y el potencial del desarrollo de alimentos funcionales y nutracéuticos con la información ya existente en la literatura científica, su uso y prescripción.
Citas
Abubaker, S. A., Alonazy, A. M., & Abdulrahman, A. (2022). Effect of Alpha-Lipoic Acid in the Treatment of Diabetic Neuropathy: A Systematic Review. Cureus, 14(6), e25750. https://doi.org/10.7759/cureus.25750
Alam, Md. A. (2019). Anti-hypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action. Frontiers in Nutrition, 6. https://www.frontiersin.org/articles/10.3389/fnut.2019.00121
Alegría-Herrera, E., Herrera-Ruiz, M., Román-Ramos, R., Zamilpa, A., Santillán-Urquiza, M. A., Aguilar, M. I., Avilés-Flores, M., Fuentes-Mata, M., & Jiménez-Ferrer, E. (2019). Effect of Ocimum basilicum, Ocimum selloi, and Rosmarinic Acid on Cerebral Vascular Damage in a Chronic Hypertension Model. Biological & Pharmaceutical Bulletin, 42(2), 201–211. https://doi.org/10.1248/bpb.b18-00574
Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J. (2017). Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management. Nutrients, 9(12), 1310. https://doi.org/10.3390/nu9121310
American Diabetes Association Professional Practice Committee. (2024). 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes Care, 47(Suppl 1), S20–S42. https://doi.org/10.2337/dc24-S002
Arenas-Jal, M., Suñé-Negre, J. M., & García-Montoya, E. (2020). Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Comprehensive Reviews in Food Science and Food Safety, 19(2), 574–594. https://doi.org/10.1111/1541-4337.12539
Argyrou, C., Karlafti, E., Lampropoulou-Adamidou, K., Tournis, S., Makris, K., Trovas, G., Dontas, I., & Triantafyllopoulos, I. K. (2020). Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia. Journal of Musculoskeletal & Neuronal Interactions, 20(1), 12–17. https://pmc.ncbi.nlm.nih.gov/articles/PMC7104583/
Arnold, M., Rajagukguk, Y. V., & Gramza-Michałowska, A. (2021). Functional Food for Elderly High in Antioxidant and Chicken Eggshell Calcium to Reduce the Risk of Osteoporosis-A Narrative Review. Foods, 10(3), 656. https://doi.org/10.3390/foods10030656
Asgary, S., Rastqar, A., & Keshvari, M. (2018). Functional Food and Cardiovascular Disease Prevention and Treatment: A Review. Journal of the American College of Nutrition, 37(5), 429–455. https://doi.org/10.1080/07315724.2017.1410867
Barber, T. M., Kabisch, S., Randeva, H. S., Pfeiffer, A. F. H., & Weickert, M. O. (2022). Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review. Nutrients, 14(14), 2870. https://doi.org/10.3390/nu14142870
Barkas, F., Bathrellou, E., Nomikos, T., Panagiotakos, D., Liberopoulos, E., & Kontogianni, M. D. (2023). Plant Sterols and Plant Stanols in Cholesterol Management and Cardiovascular Prevention. Nutrients, 15(13), 2845. https://doi.org/10.3390/nu15132845
Berdowska, I., Matusiewicz, M., & Fecka, I. (2021). Punicalagin in Cancer Prevention-Via Signaling Pathways Targeting. Nutrients, 13(8), 2733. https://doi.org/10.3390/nu13082733
Bi, Y.-L., Min, M., Shen, W., & Liu, Y. (2018). Genistein induced anticancer effects on pancreatic cancer cell lines involves mitochondrial apoptosis, G0/G1cell cycle arrest and regulation of STAT3 signalling pathway. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 39, 10–16. https://doi.org/10.1016/j.phymed.2017.12.001
Bielka, W., Przezak, A., Molęda, P., Pius-Sadowska, E., & Machaliński, B. (2024). Double diabetes-when type 1 diabetes meets type 2 diabetes: Definition, pathogenesis and recognition. Cardiovascular Diabetology, 23(1), 62. https://doi.org/10.1186/s12933-024-02145-x
Brosolo, G., Da Porto, A., Marcante, S., Picci, A., Capilupi, F., Capilupi, P., Bertin, N., Vivarelli, C., Bulfone, L., Vacca, A., Catena, C., & Sechi, L. A. (2023). Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News? International Journal of Molecular Sciences, 24(11), 9520. https://doi.org/10.3390/ijms24119520
Cai, H., Wen, Z., Zhao, L., Yu, D., Meng, K., & Yang, P. (2022). Lactobacillus plantarum FRT4 alleviated obesity by modulating gut microbiota and liver metabolome in high-fat diet-induced obese mice. Food & Nutrition Research, 66. https://doi.org/10.29219/fnr.v66.7974
Ceriello, A., & Prattichizzo, F. (2021). Variability of risk factors and diabetes complications. Cardiovascular Diabetology, 20(1), 101. https://doi.org/10.1186/s12933-021-01289-4
Chidambara Murthy, K. N., Jayaprakasha, G. K., Safe, S., & Patil, B. S. (2021). Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells. Food & Function, 12(3), 1111–1120. https://doi.org/10.1039/d0fo02740e
Chu, Z., Hu, Z., Luo, Y., Zhou, Y., Yang, F., & Luo, F. (2023). Targeting gut-liver axis by dietary lignans ameliorate obesity: Evidences and mechanisms. Critical Reviews in Food Science and Nutrition, 1–22. https://doi.org/10.1080/10408398.2023.2272269
Čižmáriková, M., Michalková, R., Mirossay, L., Mojžišová, G., Zigová, M., Bardelčíková, A., & Mojžiš, J. (2023). Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence. Biomolecules, 13(11), 1653. https://doi.org/10.3390/biom13111653
Cloete, L. (2022). Diabetes mellitus: An overview of the types, symptoms, complications and management. Nursing Standard, 37(1), 61–66. https://doi.org/10.7748/ns.2021.e11709
Cosman, F., Langdahl, B., & Leder, B. Z. (2024). Treatment Sequence for Osteoporosis. Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 30(5), 490–496. https://doi.org/10.1016/j.eprac.2024.01.014
Ditano-Vázquez, P., Torres-Peña, J. D., Galeano-Valle, F., Pérez-Caballero, A. I., Demelo-Rodríguez, P., Lopez-Miranda, J., Katsiki, N., Delgado-Lista, J., & Alvarez-Sala-Walther, L. A. (2019). The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil. Nutrients, 11(11), 2833. https://doi.org/10.3390/nu11112833
El-Baba, C., Baassiri, A., Kiriako, G., Dia, B., Fadlallah, S., Moodad, S., & Darwiche, N. (2021). Terpenoids’ anti-cancer effects: Focus on autophagy. Apoptosis: An International Journal on Programmed Cell Death, 26(9–10), 491–511. https://doi.org/10.1007/s10495-021-01684-y
Encuesta Nacional de Salud y Nutrición. (2018). Informe de Resultados de la Encuesta Nacional de Salud y Nutrición – 2018. ENSANUT. https://ensanut.insp.mx/encuestas/ensanut2018/informes.php
Ensrud, K. E., & Crandall, C. J. (2024). Osteoporosis. Annals of Internal Medicine, 177(1), ITC1–ITC16. https://doi.org/10.7326/AITC202401160
Escamilla-Nuñez, M. C., Castro-Porras, L., Romero-Martinez, M., Zárate-Rojas, E., & Rojas-Martínez, R. (2023). Detección, diagnóstico previo y tratamiento de enfermedades crónicas no transmisibles en adultos mexicanos. Ensanut 2022
Salud Publica De Mexico, 65, s153–s162. https://doi.org/10.21149/14726
Essa, M. M., Bishir, M., Bhat, A., Chidambaram, S. B., Al-Balushi, B., Hamdan, H., Govindarajan, N., Freidland, R. P., & Qoronfleh, M. W. (2023). Functional foods and their impact on health. Journal of Food Science and Technology, 60(3), 820–834. https://doi.org/10.1007/s13197-021-05193-3
Farinetti, A., Zurlo, V., Manenti, A., Coppi, F., & Mattioli, A. V. (2017). Mediterranean diet and colorectal cancer: A systematic review. Nutrition, 43–44, 83–88. https://doi.org/10.1016/j.nut.2017.06.008
Feng, Y., Zhao, Y., Liu, J., Huang, Z., Yang, X., Qin, P., Chen, C., Luo, X., Li, Y., Wu, Y., Li, X., Huang, H., Hu, F., Hu, D., Liu, Y., & Zhang, M. (2022). Consumption of Dairy Products and the Risk of Overweight or Obesity, Hypertension, and Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis and Systematic Review of Cohort Studies. Advances in Nutrition, 13(6), 2165–2179. https://doi.org/10.1093/advances/nmac096
Fernández-Sánchez, A., Madrigal-Santillán, E., Bautista, M., Esquivel-Soto, J., Morales-González, A., Esquivel-Chirino, C., Durante-Montiel, I., Sánchez-Rivera, G., Valadez-Vega, C., & Morales-González, J. A. (2011). Inflammation, oxidative stress, and obesity. International Journal of Molecular Sciences, 12(5), 3117–3132. https://doi.org/10.3390/ijms12053117
Gobierno de México. (31 de marzo de 2023). En México, más de 30 millones de personas padecen hipertensión arterial: Secretaría de Salud. Secretaría de Salud-Blog. gob.mx. http://www.gob.mx/salud/articulos/en-mexico-mas-de-30-millones-de-personas-padecen-hipertension-arterial-secretaria-de-salud
Gobierno de México. (5 de octubre de 2021). Conoce más de la diabetes para proteger y cuidar tu salud. Diabetes en México. Recuperado el 13 de febrero de 2025, de http://www.gob.mx/promosalud/acciones-y-programas/diabetes-en-mexico-284509
Gorzynik-Debicka, M., Przychodzen, P., Cappello, F., Kuban-Jankowska, A., Marino Gammazza, A., Knap, N., Wozniak, M., & Gorska-Ponikowska, M. (2018). Potential Health Benefits of Olive Oil and Plant Polyphenols. International Journal of Molecular Sciences, 19(3), 686. https://doi.org/10.3390/ijms19030686
Grochowicz, J., Fabisiak, A., & Ekielski, A. (2021). Importance of physical and functional properties of foods targeted to seniors. Journal of Future Foods, 1(2), 146–155. https://doi.org/10.1016/j.jfutfo.2022.01.004
Grönroos, R., Eggertsen, R., Bernhardsson, S., & Praetorius Björk, M. (2024). Effects of beetroot juice on blood pressure in hypertension according to European Society of Hypertension Guidelines: A systematic review and meta-analysis. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 34(10), 2240–2256. https://doi.org/10.1016/j.numecd.2024.06.009
Hayakawa, S., Ohishi, T., Miyoshi, N., Oishi, Y., Nakamura, Y., & Isemura, M. (2020). Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid. Molecules (Basel, Switzerland), 25(19), 4553. https://doi.org/10.3390/molecules25194553
Hidalgo-Lozada, G. M., Villarruel-López, A., Nuño, K., García-García, A., Sánchez-Nuño, Y. A., & Ramos-García, C. O. (2024). Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment. International Journal of Molecular Sciences, 25(5), Article 5. https://doi.org/10.3390/ijms25052671
Instituto Nacional de Estadística y Geografía. (30 de septiembre de 2022). Estadísticas a propósito del Día Internacional de las Personas Adultas Mayores. Sala de prensa. Recuperado el 18 de marzo de 2025, de https://inegi.org.mx/app/saladeprensa/noticia/7657
Instituto Nacional de Estadística y Geografía. (18 de abril de 2023). Mexico—Censo de población y vivienda 2020. Red Nacional de Metadatos. Recuperado el 15 de noviembre de 2023, de https://www.inegi.org.mx/rnm/index.php/catalog/632
Instituto Nacional de Estadística y Geografía. (s/f a). Encuesta Nacional de Ocupación y Empleo (ENOE), población de 15 años y más de edad. Información demográfica y social. Recuperado el 12 de febrero de 2025, de https://www.inegi.org.mx/programas/enoe/15ymas/
Instituto Nacional de Estadística y Geografía. (s/f b). Población. Demografía y Sociedad. Recuperado el 13 de febrero de 2025, de https://www.inegi.org.mx/temas/estructura/#publicaciones
Khalid, W., Arshad, M. S., Aziz, A., Rahim, M. A., Qaisrani, T. B., Afzal, F., Ali, A., Ranjha, M. M. A. N., Khalid, M. Z., & Anjum, F. M. (2023). Chia seeds (Salvia hispanica L.): A therapeutic weapon in metabolic disorders. Food Science & Nutrition, 11(1), 3–16. https://doi.org/10.1002/fsn3.3035
Khan, A. Q., & Uddin, S. (2021). Anticancer Activity of Natural Compounds. Asian Pacific Journal of Cancer Prevention: APJCP, 22(S1), 1–2. https://doi.org/10.31557/APJCP.2021.22.S1.1
Kloock, S., Ziegler, C. G., & Dischinger, U. (2023). Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery? Pharmacology & Therapeutics, 251, 108549. https://doi.org/10.1016/j.pharmthera.2023.108549
Koo, M. M., Swann, R., McPhail, S., Abel, G. A., Elliss-Brookes, L., Rubin, G. P., & Lyratzopoulos, G. (2020). Presenting symptoms of cancer and stage at diagnosis: Evidence from a cross-sectional, population-based study. The Lancet. Oncology, 21(1), 73–79. https://doi.org/10.1016/S1470-2045(19)30595-9
Kunutsor, S. K., Jassal, D. S., Ravandi, A., & Lehoczki, A. (2025). Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging. GeroScience. https://doi.org/10.1007/s11357-025-01512-0
Latic, N., & Erben, R. G. (2020). Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. International Journal of Molecular Sciences, 21(18), 6483. https://doi.org/10.3390/ijms21186483
Lee, Y.-M., Yoon, Y., Yoon, H., Park, H.-M., Song, S., & Yeum, K.-J. (2017). Dietary Anthocyanins against Obesity and Inflammation. Nutrients, 9(10), 1089. https://doi.org/10.3390/nu9101089
Lovic, D., Piperidou, A., Zografou, I., Grassos, H., Pittaras, A., & Manolis, A. (2020). The Growing Epidemic of Diabetes Mellitus. Current Vascular Pharmacology, 18(2), 104–109. https://doi.org/10.2174/1570161117666190405165911
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., Azizi, M., Benetos, A., Borghi, C., Hitij, J. B., Cifkova, R., Coca, A., Cornelissen, V., Cruickshank, J. K., Cunha, P. G., … Kjeldsen, S. E. (2023). 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). Journal of Hypertension, 41(12), 1874–2071. https://doi.org/10.1097/HJH.0000000000003480
Marangoni, F., Agostoni, C., Borghi, C., Catapano, A. L., Cena, H., Ghiselli, A., La Vecchia, C., Lercker, G., Manzato, E., Pirillo, A., Riccardi, G., Risé, P., Visioli, F., & Poli, A. (2020). Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects. Atherosclerosis, 292, 90–98. https://doi.org/10.1016/j.atherosclerosis.2019.11.018
Martín-Peláez, S., Fito, M., & Castaner, O. (2020). Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review. Nutrients, 12(8), 2236. https://doi.org/10.3390/nu12082236
Minamizuka, T., Koshizaka, M., Shoji, M., Yamaga, M., Hayashi, A., Ide, K., Ide, S., Kitamoto, T., Sakamoto, K., Hattori, A., Ishikawa, T., Kobayashi, J., Maezawa, Y., Kobayashi, K., Takemoto, M., Inagaki, M., Endo, A., & Yokote, K. (2021). Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial. Asia Pacific Journal of Clinical Nutrition, 30(3), 424–435. https://doi.org/10.6133/apjcn.202109_30(3).0009
Miyazawa, T., Burdeos, G. C., Itaya, M., Nakagawa, K., & Miyazawa, T. (2019). Vitamin E: Regulatory Redox Interactions. IUBMB Life, 71(4), 430–441. https://doi.org/10.1002/iub.2008
Mohammadabadi, T., & Jain, R. (2024). Cinnamon: A nutraceutical supplement for the cardiovascular system. Archives of Medical Sciences. Atherosclerotic Diseases, 9, e72–e81. https://doi.org/10.5114/amsad/184245
Morales-Franco, B., Nava-Villalba, M., Medina-Guerrero, E. O., Sánchez-Nuño, Y. A., Davila-Villa, P., Anaya-Ambriz, E. J., & Charles-Niño, C. L. (2021). Host-Pathogen Molecular Factors Contribute to the Pathogenesis of Rhizopus spp. In Diabetes Mellitus. Current Tropical Medicine Reports, 8(1), 6–17. https://doi.org/10.1007/s40475-020-00222-1
Morales-Villegas, E. C., Yarleque, C., & Almeida, M. L. (2023). Manejo de la hipertensión y dislipidemia en México: Evidencia, brechas y aproximaciones. Archivos de cardiología de México, 93(1), 77–87. https://doi.org/10.24875/acm.21000330
Moran, N. E., Thomas-Ahner, J. M., Wan, L., Zuniga, K. E., Erdman, J. W., & Clinton, S. K. (2022). Tomatoes, Lycopene, and Prostate Cancer: What Have We Learned from Experimental Models? The Journal of Nutrition, 152(6), 1381–1403. https://doi.org/10.1093/jn/nxac066
Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., & Zheng, Q. (2022). Natural Products as Anticancer Agents: Current Status and Future Perspectives. Molecules, 27(23), 8367. https://doi.org/10.3390/molecules27238367
National Center for Complementary and Integrative Health. (January, 2019). Coenzyme Q10. Health information. Recuperado el 13 de febrero de 2025, de https://www.nccih.nih.gov/health/coenzyme-q10
Nauman, M. C., & Johnson, J. J. (2019). Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers. Integrative Food, Nutrition and Metabolism, 6(2). https://doi.org/10.15761/IFNM.1000249
Nie, Q., Li, M., Huang, C., Yuan, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024). The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: A meta-analysis and systematic review. Journal of Translational Medicine, 22(1), 225. https://doi.org/10.1186/s12967-024-05011-2
Organización Mundial de la Salud. (1 de marzo de 2024). Obesidad y sobrepeso. https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight
Organización Panamericana de la Salud/Organización Mundial de la Salud. (7 de marzo de 2024). Más que una Cuestión de Peso. https://www.paho.org/es/noticias/7-3-2024-mas-que-cuestion-peso
Palacios, C. (2006). The role of nutrients in bone health, from A to Z. Critical Reviews in Food Science and Nutrition, 46(8), 621–628. https://doi.org/10.1080/10408390500466174
Pavía-López, A. A., Alcocer-Gamba, M. A., Ruiz-Gastelum, E. D., Mayorga-Butrón, J. L., Mehta, R., Díaz-Aragón, F. A., Aldrete-Velasco, J. A., López-Juárez, N., Cruz-Bautista, I., Chávez-Mendoza, A., Secchi-Nicolás, N. C., Guerrero-Martínez, F. J., Cossio-Aranda, J. E., Mendoza-Zubieta, V., Fanghänel-Salmon, G., Valdivia-Proa, M., Olmos-Domínguez, L., Aguilar-Salinas, C. A., Dávila-Maldonado, L., … Rodríguez-Vega, M. (2022). Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica. Archivos De Cardiologia De Mexico, 92(Supl), 1–62. https://doi.org/10.24875/ACM.M22000081
Pereira, P. C. (2014). Milk nutritional composition and its role in human health. Nutrition (Burbank, Los Angeles County, Calif.), 30(6), 619–627. https://doi.org/10.1016/j.nut.2013.10.011
Pierdomenico, M., Cicero, A. F. G., Veronesi, M., Fogacci, F., Riccioni, C., & Benassi, B. (2023). Effect of Citrus bergamia extract on lipid profile: A combined in vitro and human study. Phytotherapy Research: PTR, 37(9), 4185–4195. https://doi.org/10.1002/ptr.7897
Power, R., Nolan, J. M., Prado-Cabrero, A., Roche, W., Coen, R., Power, T., & Mulcahy, R. (2022). Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial. Clinical Nutrition (Edinburgh, Scotland), 41(2), 405–414. https://doi.org/10.1016/j.clnu.2021.12.004
Process for the Assessment of Scientific Support for Claims on Foods – ILSI Europe. (s/f). A European Commission Concerted Action Programme. ILSI Europe. https://ilsi.eu/eu-projects/passclaim/
Process for the Assessment of Scientific Support for Claims on Foods. (2005). European Journal of Nutrition, 44(1), i1–i2. https://doi.org/10.1007/s00394-005-1101-6
Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866
Rahayu, E. S., Mariyatun, M., Putri Manurung, N. E., Hasan, P. N., Therdtatha, P., Mishima, R., Komalasari, H., Mahfuzah, N. A., Pamungkaningtyas, F. H., Yoga, W. K., Nurfiana, D. A., Liwan, S. Y., Juffrie, M., Nugroho, A. E., & Utami, T. (2021). Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults. World Journal of Gastroenterology, 27(1), 107–128. https://doi.org/10.3748/wjg.v27.i1.107
Rajput, R., Wairkar, S., & Gaud, R. (2018). Nutraceuticals for better management of osteoporosis: An overview. Journal of Functional Foods, 47, 480–490. https://doi.org/10.1016/j.jff.2018.06.013
Ramírez-Osorio, L. J., Villarruel López, A., Villagrán, Z., & Anaya Esparza, L. M. (2022). Residuos alimenticios: Fuente de componentes bioactivos para la elaboración de alimentos funcionales. Acta de Ciencia en Salud, 16, 17-26. https://doi.org/10.32870/acs.v0i16.108
Rezazadeh, L., Alipour, B., Jafarabadi, M. A., Behrooz, M., & Gargari, B. P. (2021). Daily consumption effects of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 on oxidative stress in metabolic syndrome patients. Clinical Nutrition ESPEN, 41, 136–142. https://doi.org/10.1016/j.clnesp.2020.12.003
Rocha, V. Z., Tada, M. T., Chacra, A. P. M., Miname, M. H., & Mizuta, M. H. (2023). Update on Sitosterolemia and Atherosclerosis. Current Atherosclerosis Reports, 25(5), 181–187. https://doi.org/10.1007/s11883-023-01092-4
Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., & Bernini, R. (2019). Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L. Nutrients, 11(8), 1776. https://doi.org/10.3390/nu11081776
Saadat, N., Akhtar, S., Goja, A., Razalli, N. H., Geamanu, A., David, D., Shen, Y., & Gupta, S. V. (2018). Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model. Nutrition and Cancer, 70(7), 1075–1087. https://doi.org/10.1080/01635581.2018.1502327
Sanchez, M., Darimont, C., Drapeau, V., Emady-Azar, S., Lepage, M., Rezzonico, E., Ngom-Bru, C., Berger, B., Philippe, L., Ammon-Zuffrey, C., Leone, P., Chevrier, G., St-Amand, E., Marette, A., Doré, J., & Tremblay, A. (2014). Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. The British Journal of Nutrition, 111(8), 1507–1519. https://doi.org/10.1017/S0007114513003875
Sánchez-Nuño, Y. A., Zermeño-Ruiz, M., Vázquez-Paulino, O. D., Nuño, K., & Villarruel-López, A. (2024). Bioactive Compounds from Pigmented Corn (Zea mays L.) and Their Effect on Health. Biomolecules, 14(3), 338. https://doi.org/10.3390/biom14030338
Sbehat, M., Mauriello, G., & Altamimi, M. (2022). Microencapsulation of Probiotics for Food Functionalization: An Update on Literature Reviews. Microorganisms, 10(10), 1948. https://doi.org/10.3390/microorganisms10101948
Schoeneck, M., & Iggman, D. (2021). The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases, 31(5), 1325–1338. https://doi.org/10.1016/j.numecd.2020.12.032
Secretaría de Salud, (16 de septiembre de 2023). 294. México registra al año más de 195 mil casos de cáncer: Secretaría de Salud. gob.mx. Recuperado el 4 de julio de 2024, de http://www.gob.mx/salud/prensa/294-mexico-registra-al-ano-mas-de-195-mil-casos-de-cancer-secretaria-de-salud
Shahcheraghi, S. H., Salemi, F., Small, S., Syed, S., Salari, F., Alam, W., Cheang, W. S., Saso, L., & Khan, H. (2023). Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects. Phytotherapy Research: PTR, 37(4), 1590–1605. https://doi.org/10.1002/ptr.7754
Shatylo, V. B., Korkushko, O. V., Borovs’kyĭ, V. R., Anisimova, I. M., Tarasenko, O. B., & Ivanova, A. O. (2007). [Efficacy of treatment-and-prophylactic diets including soya-based food in elderly patients with atherogenic dislipidemia and glucose intolerance]. Likars’ka Sprava, 5–6, 89–97. https://europepmc.org/article/MED/18416170
Shirouchi, B., Nagao, K., Umegatani, M., Shiraishi, A., Morita, Y., Kai, S., Yanagita, T., Ogawa, A., Kadooka, Y., & Sato, M. (2016). Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure. The British Journal of Nutrition, 116(3), 451–458. https://doi.org/10.1017/S0007114516002245
Siegel, R. L., Giaquinto, A. N., & Jemal, A. (2024). Cancer statistics, 2024. CA: A Cancer Journal for Clinicians, 74(1), 12–49. https://doi.org/10.3322/caac.21820
Silva, B. V., Sousa, C., Caldeira, D., Abreu, A., & Pinto, F. J. (2022). Management of arterial hypertension: Challenges and opportunities. Clinical Cardiology, 45(11), 1094–1099. https://doi.org/10.1002/clc.23938
Sleiman, C., Daou, R.-M., Al Hazzouri, A., Hamdan, Z., Ghadieh, H. E., Harbieh, B., & Romani, M. (2024). Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications. Nutrients, 16(17), 2895. https://doi.org/10.3390/nu16172895
Soliman, G. A. (2019). Dietary Fiber, Atherosclerosis, and Cardiovascular Disease. Nutrients, 11(5), 1155. https://doi.org/10.3390/nu11051155
Song, R., Hu, M., Qin, X., Qiu, L., Wang, P., Zhang, X., Liu, R., & Wang, X. (2023). The Roles of Lipid Metabolism in the Pathogenesis of Chronic Diseases in the Elderly. Nutrients, 15(15), 3433. https://doi.org/10.3390/nu15153433
Song, Y., Wang, Q., & Jia, L. (2024). Omega-3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach. Journal of Clinical Hypertension, 26(4), 382–390. https://doi.org/10.1111/jch.14782
Subramaniam, S., Selvaduray, K. R., & Radhakrishnan, A. K. (2019). Bioactive Compounds: Natural Defense Against Cancer? Biomolecules, 9(12), 758. https://doi.org/10.3390/biom9120758
Terasaki, M., Kubota, A., Kojima, H., Maeda, H., Miyashita, K., Kawagoe, C., Mutoh, M., & Tanaka, T. (2021). Fucoxanthin and Colorectal Cancer Prevention. Cancers, 13(10), 2379. https://doi.org/10.3390/cancers13102379
Tousoulis, D. (2020). Arterial hypertension: New concepts in diagnosis and treatment? Hellenic Journal of Cardiology: HJC = Hellenike Kardiologike Epitheorese, 61(3), 145–147. https://doi.org/10.1016/j.hjc.2020.08.003
Tupas, G., Otero, M. C., & Bernolo, L. (2020). Title: Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations Chapter 1 Functional Foods and Health Benefits. https://doi.org/10.13140/RG.2.2.18636.77440
Van Loon, K., Mohar, A., Unger-Saldaña, K., Potter, M. B., Sweet-Cordero, E. A., Breithaupt, L., Espinosa-Tamez, P., Sepúlveda-Amor, J., & Lajous, M. (2022). Developing a collaborative international partnership for cancer control in Mexico. Salud Publica De Mexico, 64(1), 100–104. https://doi.org/10.21149/12506
Wang, Q., Shen, W., Shao, W., & Hu, H. (2024). Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice. Biochemical and Biophysical Research Communications, 719, 150088. https://doi.org/10.1016/j.bbrc.2024.150088
Xu, L., Li, Y., Dai, Y., & Peng, J. (2018). Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms. Pharmacological Research, 130, 451–465. https://doi.org/10.1016/j.phrs.2018.01.015
Yin, Y., Tan, Y., Wei, X., Li, X., Chen, H., Yang, Z., Tang, G., Yao, X., Mi, P., & Zheng, X. (2022). Recent Advances of Curcumin Derivatives in Breast Cancer. Chemistry & Biodiversity, 19(10), e202200485. https://doi.org/10.1002/cbdv.202200485
Younas, A., Naqvi, S. A., Khan, M. R., Shabbir, M. A., Jatoi, M. A., Anwar, F., Inam-Ur-Raheem, M., Saari, N., & Aadil, R. M. (2020). Functional food and nutra-pharmaceutical perspectives of date (Phoenix dactylifera L.) fruit. Journal of Food Biochemistry, 44(9), e13332. https://doi.org/10.1111/jfbc.13332
Zarrati, M., Shidfar, F., Nourijelyani, K., Mofid, V., Hossein zadeh-Attar, M. J., Bidad, K., Najafi, F., Gheflati, Z., Chamari, M., & Salehi, E. (2013). Lactobacillus acidophilus La5, Bifidobacterium BB12, and Lactobacillus casei DN001 modulate gene expression of subset specific transcription factors and cytokines in peripheral blood mononuclear cells of obese and overweight people. BioFactors (Oxford, England), 39(6), 633–643. https://doi.org/10.1002/biof.1128
Zhang, Y., Yang, S., Wu, Q., Ye, Z., Zhou, C., Liu, M., Zhang, Z., He, P., Zhang, Y., Li, H., Li, R., Gan, X., Liu, C., & Qin, X. (2023). Dietary vitamin E intake and new-onset hypertension. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 46(5), 1267–1275. https://doi.org/10.1038/s41440-022-01163-0
Zhou, Y., Farooqi, A. A., & Xu, B. (2023). Comprehensive review on signaling pathways of dietary saponins in cancer cells suppression. Critical Reviews in Food Science and Nutrition, 63(20), 4325–4350. https://doi.org/10.1080/10408398.2021.2000933
